Monday, April 27, 2009

Watson V Jeopardy

IBM's Blue Gene supercomputer is preparing to face Jeopardy! champions. In the latest popular supercomputing challenge, Blue Gene, running a program named Watson after the IBM founder, will match wits with the game show contestants. IBM's most famous computing challenge was Deep Blue's disputed chess victory over world champion Garry Kasparov.

The myriad Jeopardy! word plays and the subtleties of the English language pose serious challenges for Blue Gene. The most serious challenge to Jeopardy! to date was, of course, Sean Connery.

(image credit: IBM's Deep Blue supercomputer, wikipedia.org)

Wednesday, April 22, 2009

Blue Brain

A reverse-engineered, molecule-specific mammalian brain simulation has reached its first step - a rough simulation of the neocortical column. Researchers from the Blue Brain Project announced the advance at the European Future Technologies assembly in Prague.

On a related note, check out the Allen Institute for Brain Science's neuro atlases.

(image credit: SPL, via bbc.co.uk)

Tuesday, April 21, 2009

Benefits of Lice

Lice have been shown to suppress mammalian immune systems, suggesting that their removal from humans may have fostered hyperimmune responses like asthma.

(image credit: nih.gov)

Monday, April 20, 2009

The Return of Cold Fusion

Martin Fleischmann seems stunned by this development.


Watch CBS Videos Online

Information Medicine

The Economist ponders bioinformatics and the future of medicine.

"Crazy Sickness"

The BBC is reporting that a new outbreak of "Grisi Siknis" (Crazy Sickness) amongst the Moskito people of Nicaragua is being studied. After successive stages of mania and delirium, which can be quite violent, the sufferer collapses into a coma-like state. In "Grisis Siknis in Moskito Culture", Philip A. Dennis relates that the disease is "epidemic and contagious in form," a finding supported by recent data. Yet medicine can identify no physical cause. This raises interesting questions about the way involuntary behaviors propagate themselves.

According to the unlikely-named Pablo McDavis of Uraccan University, "We have taken samples of blood from patients while suffering an attack and, in a lab, we can't detect anything. Drugs or injections tend to only increase a patient's aggressiveness. Clinically we can't detect anything. It is like an outbreak. If an attack is not contained quickly, it can spread throughout an entire community."

It is only known to afflict the Moskito. Though it seems to mainly afflict young women, it crosses gender barriers, with sufferers reporting gender-specific hallucinations of a violent, sexual nature in which impressive members of the opposite sex seduce the victim and give them socially unacceptable commands. To say that a culture is unique is redundant, but the ethnic and genetic diversity of the Moskito is unique, presenting a blend of Native Central American, European, Creole African, and Chinese elements. The remoteness and idiosyncrasy of the culture may lead many to write off "Grisi Siknis" as a quirk of a backwards tribe, but that would be culturally chauvinistic.

Though the focus on the cultural specificity of the disease is understandable, it brings to mind other mysterious mass hysterical phenomena, such as St. Vitus's Dance (after the patron saint of dance, adolescents, and dogs.) It is the kind of disease that seems to belong to another time, like King's Evil (scrofula). In our own time it is more likely to inspire modern music than fear of the lord, but in the middle ages it reportedly afflicted groups large enough to collapse the bridges they danced across. Now usually called Sydenham's Chorea, it is recognized as a neurological movement disorder that can follow acute rheumatic fever arising from throat infections caused by streptococcal bacteria. The relationship between the identifiable neurological disorder and its cultural/mass hysterical dimension has yet to be explained.

Among the Saora of the Orissa Province of India, a small number of young adults complain of total-body stinging sensations, display culturally-inapropriate laughter and tears, and are prone to unexplained fainting spells. The elders of the Saora say that powerful spirits of the opposite sex are attempting to seduce the youths. The "cure" is usually a ritual marriage with the spirit. It is reported to bring an end to the complaint, and the erstwhile sufferers often go on to become traditional healers themselves.

But St. Vitus's Dance was not violent, nor are the Saora Spirit Courtships. There are perhaps other relevant parallels with "Running Amok." Most are familiar with the phrase "To Run Amok," but fewer people are aware of its origins in seemingly random acts of frenzied homicidal assault in South East Asia (what was the Dutch East Indies.) It has murky pathological roots, being more akin to the mass murderous rages of our own time, which we associate with mental illness, than to either mass hysteria or contagious disease. Yet, in the descriptions of the frenzy, it brings to mind the "Grisi Siknis" that purportedly caused inhabitants of Moskito villages to chase each other with machetes. According to Phrase Finder, the term was "first alluded to in the 1516 text Barbosa . . . 'There are some of them [the Javanese] who go out into the streets, and kill as many persons as they meet. These are called Amuco.'" There was an underlying cultural code to give it some context, but the salient feature of "Running Amok" seems to have been a certain inexplicability. This sort of behavior seems to propogate itself, but how?
From video to marketing "Viral" is a term that is rapidly losing the glow of its buzzy-ness, but the the concept of Memes, pioneered by F.T. Cloak and popularized by Richard Dawkins and Daniel Dennett, only gains in gravity what it loses in a novelty. The book "Connected" by Steven Shaviro exposes the intellectual debts those who trade in cultural viruses owe to Evolutionary Biology. Perhaps study of the transmission of complex involuntary behaviors could lead us to new understanding of both consciousness and culture.

(Thanks to Pro Nova Music for the image and interesting Website)

Tuesday, April 14, 2009

Monsieur O'Keefe

Bob Williams returns with a piece on grudges and French class.

MONSIEUR O'KEEFE

Grudges are heavy burdens to carry over a long period of time. I know. I have carried one for more than forty years. I am not particularly proud of my grudge; it is not especially noble. But it is mine, and I have taken pains to cultivate it on a regular basis. In turn, it has always been there when I’ve needed it.

My grudge dates back to 1966-67, my first year at Duke. Shortly after arriving on campus, my fellow freshmen and I were given a series of placement exams. One was for foreign language. As it turned out, three years of goofing around in SeƱor Marvin Woodard’s high school Spanish classes did little to prepare me for the expectations of the Duke foreign language department. Consequently, I scored too low on the Spanish exam to place into the second year, and I had too many years of high school Spanish to qualify for the beginning course. My only option was to take another language. My choice was French. I forget why.

continue Bob Williams's MONSIEUR O'KEEFE

Sunday, April 12, 2009

More TED

Bonnie Bassler on bacterial communication and the reminder that we are mostly microbes.

Sunday, April 5, 2009

Human Flight

Ueli Gegenschatz discusses and show videos of his wingsuit flight.

Eat Lightning

Newly discovered bacteria can eat electricity and make methane gas. They could potentially be used to store power.

Wednesday, April 1, 2009

Making Blood

Penn researchers have made a protein that can carry oxygen, a potentially significant breakthrough in creating artificial blood.

(image credit: Dutton Lab, via technologyreview)